TABLE 4.
Associations between dietary patterns and CSF biomarker levels
| Total n = 269 | Total n = 268 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 a | Model 2 a | |||||||||
| Aβ42 | B | 95% CI | S.E | r2 | P‐value | B | 95% CI | S.E | Adj. r² | P‐value |
| Western | –11.96 | –39.96;16.05 | 14.22 | 0.003 | .40 | –3.31 | –36.23;29.60 | 16.72 | 0.000 | .84 |
| Mediterranean/prudent | –14.41 | –40.88;12.07 | 13.44 | 0.004 | .29 | –6.81 | –35.86;22.23 | 14.75 | 0.001 | .65 |
| High‐protein and alcohol | 6.04 | –20.71;32.80 | 13.59 | 0.001 | .66 | 23.79 | –7.37;54.95 | 15.82 | 0.009 | .13 |
| High‐total and saturated fat | 5.18 | –20.38;30.72 | 12.98 | 0.001 | .69 | 15.29 | –12.57;43.16 | 14.15 | 0.005 | .28 |
| Aβ42/ Aβ40 b | B | 95% CI | S.E | r2 | P‐value | B | 95% CI | S.E | Adj. r² | P‐value |
|---|---|---|---|---|---|---|---|---|---|---|
| Western | –0.002 | –0.005;0.000 | 0.001 | 0.011 | .09 | –0.002 | –0.005;0.001 | 0.002 | 0.018 | .16 |
| Mediterranean/ prudent | –0.001 | –0.004;0.001 | 0.001 | 0.004 | .28 | 0.000 | –0.003;0.002 | 0.001 | 0.010 | .83 |
| High‐protein and alcohol | 0.001 | –0.002;0.004 | 0.001 | 0.002 | .44 | 0.003 | 0.000;0.006 | 0.001 | 0.022 | .08 |
| High‐total and saturated fat | 0.001 | –0.002;0.003 | 0.001 | 0.001 | .67 | 0.001 | –0.001;0.004 | 0.001 | 0.014 | .29 |
| T‐tau | B | 95% CI | S.E | r2 | P‐value | B | 95% CI | S.E | Adj. r² | P‐value |
|---|---|---|---|---|---|---|---|---|---|---|
| Western | 0.04 | –0.01;0.09 | 0.02 | 0.012 | .08 | 0.05 | –0.10:0.10 | 0.03 | 0.006 | .11 |
| Mediterranean/ prudent | –0.02 | –0.07;0.02 | 0.02 | 0.004 | .30 | –0.04 | –0.09;0.01 | 0.02 | 0.008 | .08 |
| High‐protein and alcohol | –0.01 | –0.05;0.04 | 0.02 | 0.000 | .79 | –0.02 | –0.08;0.03 | 0.03 | 0.000 | .38 |
| High‐total and saturated fat | 0.03 | –0.01;0.07 | 0.02 | 0.008 | .15 | 0.02 | –0.02;0.07 | 0.02 | 0.000 | .31 |
| P‐tau | B | 95% CI | S.E | r2 | P‐value | B | 95% CI | S.E | Adj. r² | P‐value |
|---|---|---|---|---|---|---|---|---|---|---|
| Western | 0.04 | –0.01;0.08 | 0.02 | 0.011 | .09 | 0.03 | –0.02;0.08 | 0.03 | 0.015 | .21 |
| Mediterranean/prudent | –0.00 | –0.04;0.04 | 0.02 | 0.000 | .97 | –0.02 | –0.07;0.02 | 0.02 | 0.012 | .32 |
| High‐protein and alcohol | 0.01 | –0.03;0.05 | 0.02 | 0.001 | .59 | 0.00 | –0.05;0.05 | 0.02 | 0.009 | .97 |
| High‐total and saturated fat | 0.04 | –0.01;0.08 | 0.02 | 0.014 | .06 | 0.03 | –0.02;0.07 | 0.02 | 0.014 | .22 |
| P‐tau/ Aβ42 | B | 95% CI | S.E | r2 | P‐value | B | 95% CI | S.E | Adj. r² | P‐value |
|---|---|---|---|---|---|---|---|---|---|---|
| Western | 0.063 | 0.001;0.125 | 0.031 | 0.015 | .05 | 0.042 | –0.030;0.114 | 0.036 | 0.038 | .25 |
| Mediterranean/prudent | 0.030 | –0.029;0.088 | 0.030 | 0.004 | .32 | –0.006 | –0.069;0.058 | 0.032 | 0.034 | .86 |
| High‐protein and alcohol | 0.001 | –0.059;0.060 | 0.030 | 0.000 | .98 | –0.041 | –0.109;0.027 | 0.035 | 0.039 | .24 |
| High‐total and saturated fat | 0.030 | –0.027;0.086 | 0.029 | 0.004 | .30 | –0.002 | –0.063;0.059 | 0.031 | 0.033 | .96 |
a
Analyses in model 1 is unadjusted for confounders. Potential confounders included in model 2 are: BMI, energy intake, sex, physical activity level, educational level. One participant had missing physical activity level data. T‐tau, p‐tau, and the p‐tau/Aβ42 ratio were log‐transformed to normalize the distribution.
b
Three participants had missing Aβ42/40 values.