TABLE 2.
Demographic, clinical, and pathological features of patients
| Severe ADNC | Severe ADNC Limbic LBP | Severe ADNC Neocortical LBP | Moderate ADNC Neocortical LBP | Neocortical LBP | P | |
|---|---|---|---|---|---|---|
| N | 31 | 10 | 18 | 15 | 7 | |
| M:F | 16:15 | 3:7 | 8:10 | 12:3 | 6:1 | .041 |
| Age of symptom onset (y) a | 63.7 ± 8.3 | 65.7 ± 9.0 | 62.2 ± 10.0 | 65.1 ± 7.9 | 65.3 ± 9.0 | .016 |
| Age of dementia onset (y) a | 66.7 ± 8.8 | 67.7 ± 9.3 | 64.3 ± 9.3 | 74.6 ± 6.7 | 67.3 ± 8.8 | .018 |
| Survival from symptom onset (y) a | 9.8 ± 3.3 | 9.6 ± 3.6 | 10.5 ± 4.9 | 7.2 ± 2.4 | 7.0 ±1.8 | .001 |
| Survival from dementia onset (y) a | 6.9 ± 2.8 | 7.6 ± 3.4 | 8.4 ± 4.7 | 4.6 ± 2.0 | 4.9 ± 2.2 | .009 |
| MMSE score at presentation a | 23.6 ± 4.6 | 19.7 ± 6.3 | 20.6 ± 6.8 | 23.0 ± 4.9 | 22.0 ± 5.7 | .2 |
| Memory symptoms (%) | 96.8 | 90 | 100 | 100 | 71.4 | .03 |
| Visuospatial deficit (%) | 34.3 | 14.3 | 8.6 | 28.6 | 14.3 | .02 |
| Parkinsonism (%) | 9.7 | 20 | 16.7 | 40 | 71.4 | .005 |
| Visual hallucinations (%) | 3.2 | 10 | 11.1 | 40 | 14.3 | .02 |
| Cognitive fluctuation (%) | 3.2 | 0 | 0 | 40 | 0 | .001 |
| RBD (%) | 0 | 0 | 25 | 50 | 25 | .02 |
| Autonomic dysfunction (%) | 12.9 | 10 | 61 | 73.3 | 85.7 | .0001 |
| Neuroleptic sensitivity (%) | 3.2 | 0 | 0 | 13.3 | 14.3 | .267 |
| Brain weight (gms) a | 1178±157 | 1193±112 | 1173±113 | 1340±150 | 1435±155 | .007 |
a
Values are expressed as mean ± SD.
Abbreviations: ADNC, Alzheimer's disease neuropathological change; LBP, Lewy body pathology; MMSE, Mini‐Mental State Examination; RBD, REM sleep behavior disorder; SD, standard deviation.