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. Author manuscript; available in PMC: 2021 May 18.
Published in final edited form as: Cell Metab. 2018 Jul 26;28(5):787–792.e3. doi: 10.1016/j.cmet.2018.07.002

Figure 2. No Lineage Tracing Evidence of α-to-β Cell Trans-differentiation After Artesunate or GABA Treatment.

Figure 2.

(A) Representative immunofluorescent image of islet from a saline-treated mouse.

(B-F) are magnified view of area outlined in (A).

(G) Representative immunofluorescent image of islet from a GABA-treated mouse.

(H-L) are magnified view of area outlined in (G).

(M) Representative immunofluorescent image of islet from an artesunate-treated mouse.

(N-R) are magnified view of area outlined in (M).

Yellow arrows indicate Insulin+/YFP+ cells. Scale bars represent 20 μm. INS = Insulin, GCG = Glucagon

(S) Quantification of % YFP+ cells that are also lnsulin+, as depicted in (A-M). Data points from individual mice are presented with mean ± standard deviation. No significant differences were detected by one-way ANOVA with Sidak correction for multiple comparisons.