Table 3.
Effects of acotiamide on gastrointestinal function
| Esophageal motor function |
LES pressure |
EGJ compliance |
Gastric emptying |
Gastric accommodation |
|
|---|---|---|---|---|---|
| Ishimura et al.(25) | → (HV) | ||||
| Zai et al.(5) | → (HV) | ||||
| Mikami et al.(26) | → (HV) → (GERD) | → (HV) → (GERD) | → (HV) → (GERD) | ||
| Nakamura et al.(6) | ↑ (FD) | ↑ (FD) | |||
| Masuy et al.(7) | → (HV) | ||||
| Funaki et al.(27) | ↑ (FD) |
→: No change. ↑: Acceleration. LES, lower esophageal sphincter; EGJ, esophagogastric junction; HV, healthy volunteer; GERD, gastroesophageal reflux disease; FD, functional dyspepsia; PPI, proton pump inhibitor.