Table 3.

Subgroup analysis of the risk of stroke

		No. of studies	RR (95% CI)	Heterogeneity p	p
Serum UA level
1	Age (mean/median)
	>50	19	1.26 (1.17–1.35)	0.001	<0.001
	≤50	8	1.12 (1.06–1.18)	0.7	<0.001
2	Percentage of women
	>45	16	1.24 (1.14–1.34)	0.001	<0.001
	≤45	11	1.20 (1.08–1.34)	0.006	0.001
3	No. of participants
	>15,000	9	1.21 (1.11–1.32)	0.001	<0.001
	≤15,000	18	1.23 (1.14–1.34)	0.2	<0.001
4	No. of cases
	>500	8	1.21 (1.11–1.33)	0.001	<0.001
	≤500	19	1.22 (1.13–1.32)	0.3	<0.001
5	Location
	United States	2	1.23 (0.88–1.71)	0.2	0.226
	Europe	12	1.20 (1.11–1.29)	0.001	<0.001
	Aisa	13	1.28 (1.16–1.41)	0.4	<0.001
6	Follow-up time
	>10	15	1.20 (1.12–1.29)	0.001	<0.001
	≤10	12	1.29 (1.14–1.44)	0.3	<0.001
7	Quality
	>7	20	1.22 (1.14–1.30)	0.001	<0.001
	≤7	7	1.26 (1.08–1.47)	0.1	0.003
8	Adjusted
	Yes	25	1.22 (1.15–1.30)	0.001	<0.001
	No	2	1.08 (0.61–1.91)	0.9	0.791
9	Subtype of stroke
	Ischemic stroke	16	1.34 (1.24–1.45)	0.2	<0.001
	Hemorrhagic stroke	9	1.41 (1.12–1.77)	0.01	0.004
10	Sex
	Male	13	1.20 (1.12–1.29)	0.001	<0.001
	Female	11	1.27 (1.30–1.47)	0.001	<0.001