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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Clin Infect Dis. 2021 Jun 1;72(11):2000–2005. doi: 10.1093/cid/ciaa466

Table 2.

Age-Stratified Vaccine Effectiveness Estimates for the Effect of Complete-Series Rotavirus Vaccination Against Medically Attended Rotavirus Acute Gastroenteritis (Any Encounter Type) and Acute Gastroenteritis Resulting in Outpatient Care

qRT-PCRa qRT-PCR With Cq cutoff <27a qRT-PCR + and EIAb EIAc
VE (95% CI) P VE (95% CI) P VE (95% CI) P VE (95% CI) P
All encounter types
 All age-eligible childrend 70 (37, 86) .002 72 (31, 89) .005 73 (32, 90) .006 62 (−20, 88) .10
 <2 years of age 90 (71, 96) <.0001 90 (62, 97) .0006 90 (69, 96) <.0001 87 (−51, 99) .10
 2 to <5 years of age 40 (−182, 87) .51 53 (−127, 90) .35 Cannot estimate … 77 (−22, 96) .084
 5–11 years of age 32 (−199, 85) .61 39 (−283, 90) .60 59 (−567, 98) .53 18 (−372, 86) .83
Ambulatory clinic and emergency department encounters only
 All age-eligible childrend 70 (37, 86) .002 73 (33, 89) .005 74 (33, 90) .005 61 (−22, 88) .11
 <2 years of age 89 (70, 96) <.0001 89 (61, 97) .0007 89 (68, 96) <.0001 86 (−55, 99) .11
 2 to <5 years of age 45 (−164, 88) .46 57 (−110, 91) .29 Cannot estimate … 77 (−22, 96) .084
 5–11 years of age 31 (−207, 84) .63 37 (−292, 90) .62 58 (−585, 97) .54 15 (−385, 85) .85

Abbreviations: CDC, Centers for Disease Control and Prevention; CI, confidence interval; Cq, quantification cycle; EIA, enzyme immunoassay; OSHPL, Oregon State Public Health Laboratory; qRT-PCR, reverse transcription–quantitative real-time polymerase chain reaction; VE, vaccine effectiveness.

a

Excludes 2 samples that were rotavirus positive at OSPHL but not shipped to the CDC and 4 samples that were rotavirus qRT-PCR positive at OSPHL but not qRT-PCR positive at CDC.

b

Excludes 2 samples that were rotavirus positive at OSPHL but not shipped to CDC, 4 samples that were rotavirus qRT-PCR positive at OSPHL but not qRT-PCR positive at CDC, and 17 samples that were qRT-PCR and EIA positive at CDC.

c

Excludes 2 samples that were rotavirus positive at OSPHL but not shipped to CDC and 4 samples that were rotavirus qRT-PCR positive at OSPHL but not qRT-PCR positive at CDC; 32 samples that were qRT-PCR positive but EIA negative are included as EIA-negative samples.

d

Results adjusted for age group.