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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Comparison 1. 5‐HT3 antagonists vs placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Nausea ‐ intraoperative 12 1419 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.42, 0.71]
1.1.1 Ondansetron ‐ 4 mg 9 1111 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.41, 0.73]
1.1.2 Ondansetron ‐ 8 mg 1 32 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.20, 1.01]
1.1.3 Granisetron ‐ 1 mg 1 176 Risk Ratio (M‐H, Random, 95% CI) 1.14 [0.59, 2.20]
1.1.4 Granisetron 3 mg 1 100 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.18, 0.61]
1.2 Vomiting ‐ intraoperative 11 1414 Risk Ratio (M‐H, Random, 95% CI) 0.46 [0.29, 0.73]
1.2.1 Ondansetron ‐ 4 mg 8 1059 Risk Ratio (M‐H, Random, 95% CI) 0.51 [0.31, 0.84]
1.2.2 Ondansetron ‐ 8 mg 1 32 Risk Ratio (M‐H, Random, 95% CI) 0.14 [0.02, 1.03]
1.2.3 Granisetron ‐ 1 mg 1 176 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.19, 2.28]
1.2.4 Tropisotron 2 mg 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.09 [0.01, 0.67]
1.3 Nausea ‐ postoperative 10 1340 Risk Ratio (M‐H, Random, 95% CI) 0.40 [0.30, 0.54]
1.3.1 Ondansetron ‐ 4 mg 8 1023 Risk Ratio (M‐H, Random, 95% CI) 0.39 [0.26, 0.58]
1.3.2 Ondansetron ‐ 8 mg 1 90 Risk Ratio (M‐H, Random, 95% CI) 0.44 [0.18, 1.09]
1.3.3 Granisetron ‐ 40 mcg/kg 1 80 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.14, 0.90]
1.3.4 Tropisotron ‐ 2 mg 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.46 [0.12, 1.71]
1.4 Vomiting ‐ postoperative 10 1450 Risk Ratio (M‐H, Random, 95% CI) 0.47 [0.31, 0.69]
1.4.1 Ondansetron ‐ 4 mg 8 1133 Risk Ratio (M‐H, Random, 95% CI) 0.44 [0.27, 0.71]
1.4.2 Ondansetron ‐ 8 mg 1 90 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.19, 5.15]
1.4.3 Granisetron ‐ 40 mcg/kg 1 80 Risk Ratio (M‐H, Random, 95% CI) 0.43 [0.12, 1.54]
1.4.4 Tropisotron ‐ 2 mg 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.21 [0.01, 4.38]
1.5 'Nausea + Vomiting' ‐ intraoperative (not pre‐specified) 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.53, 0.97]
1.5.1 Tropisotron ‐ 2 mg 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.53, 0.97]
1.6 'Nausea + Vomiting' ‐ postoperative ‐ (not pre‐specified) 5 576 Risk Ratio (M‐H, Random, 95% CI) 0.57 [0.41, 0.80]
1.6.1 Ondansetron ‐ 4 mg 3 255 Risk Ratio (M‐H, Random, 95% CI) 0.68 [0.40, 1.13]
1.6.2 Ondansetron ‐ 8 mg 1 100 Risk Ratio (M‐H, Random, 95% CI) 0.38 [0.19, 0.72]
1.6.3 Tropisotron ‐ 2 mg 1 147 Risk Ratio (M‐H, Random, 95% CI) 0.46 [0.12, 1.71]
1.6.4 Granisetron ‐ 0.1 mg 1 74 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.22, 2.31]
1.7 Maternal satisfaction 2   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
1.7.1 Ondansetron ‐ 4 mg 2   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
1.7.2 Ondansetron ‐ 8 mg 0   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
1.7.3 Granisetron ‐ 1 mg 0   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
1.7.4 Granisetron ‐ 3 mg 0   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
1.8 Maternal adverse outcomes 1 100 Risk Ratio (M‐H, Random, 95% CI) Not estimable
1.8.1 Ondansetron ‐ 8 mg 1 100 Risk Ratio (M‐H, Random, 95% CI) Not estimable
1.9 Headache/dizziness/vertigo 4 433 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.60, 1.79]
1.9.1 Ondansetron ‐ 4 mg 4 433 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.60, 1.79]
1.10 Hypotension 3 290 Risk Ratio (M‐H, Random, 95% CI) 1.22 [0.72, 2.08]
1.10.1 Ondansetron ‐ 4 mg 2 114 Risk Ratio (M‐H, Random, 95% CI) 1.44 [0.48, 4.34]
1.10.2 Granisetron ‐ 1 mg 1 176 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.12, 72.65]
1.11 Pruritus/itching 4 488 Risk Ratio (M‐H, Random, 95% CI) 0.85 [0.69, 1.05]
1.11.1 Ondansetron ‐ 4 mg 3 298 Risk Ratio (M‐H, Random, 95% CI) 0.65 [0.36, 1.14]
1.11.2 Ondansetron ‐ 8 mg 2 190 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.84, 1.05]
1.12 Dry mouth 1 130 Risk Ratio (M‐H, Random, 95% CI) 0.75 [0.17, 3.22]
1.12.1 Ondansetron ‐ 4 mg 1 130 Risk Ratio (M‐H, Random, 95% CI) 0.75 [0.17, 3.22]
1.13 Drowsiness/sedation 2 170 Risk Ratio (M‐H, Random, 95% CI) 3.94 [0.45, 34.63]
1.13.1 Ondansetron ‐ 4 mg 2 170 Risk Ratio (M‐H, Random, 95% CI) 3.94 [0.45, 34.63]
1.14 Rescue antiemetic (not pre‐specified) 1 158 Risk Ratio (M‐H, Random, 95% CI) 0.32 [0.11, 0.93]