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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Comparison 2. Dopamine antagonists vs placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Nausea ‐ intraoperative 15 1180 Risk Ratio (M‐H, Random, 95% CI) 0.38 [0.27, 0.52]
2.1.1 Metoclopramide ‐ 10 mg 10 748 Risk Ratio (M‐H, Random, 95% CI) 0.39 [0.24, 0.62]
2.1.2 Metoclopramide ‐ 20 mg 1 100 Risk Ratio (M‐H, Random, 95% CI) 0.27 [0.10, 0.75]
2.1.3 Metoclopramide ‐ 0.15 mg/kg 1 67 Risk Ratio (M‐H, Random, 95% CI) 0.32 [0.12, 0.90]
2.1.4 Droperidol ‐ 0.5 mg 1 128 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.17, 0.65]
2.1.5 Droperidol ‐ 0.625 mg 1 32 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.15, 0.90]
2.1.6 Droperidol ‐ 1.25 mg 1 75 Risk Ratio (M‐H, Random, 95% CI) 0.44 [0.17, 1.15]
2.1.7 Droperidol ‐ 5 mg 1 30 Risk Ratio (M‐H, Random, 95% CI) 0.30 [0.09, 1.01]
2.2 Vomiting ‐ intraoperative 12 942 Risk Ratio (M‐H, Random, 95% CI) 0.41 [0.28, 0.60]
2.2.1 Metoclopramide ‐ 10 mg 8 610 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.27, 0.76]
2.2.2 Metoclopramide ‐ 0.15 mg/kg 1 67 Risk Ratio (M‐H, Random, 95% CI) 0.09 [0.01, 1.54]
2.2.3 Droperidol ‐ 0.5 mg 1 128 Risk Ratio (M‐H, Random, 95% CI) 0.34 [0.09, 1.23]
2.2.4 Droperidol ‐ 0.625 mg 1 32 Risk Ratio (M‐H, Random, 95% CI) 0.29 [0.07, 1.17]
2.2.5 Droperidol ‐ 1.25 mg 1 75 Risk Ratio (M‐H, Random, 95% CI) 0.37 [0.10, 1.27]
2.2.6 Droperidol ‐ 5 mg 1 30 Risk Ratio (M‐H, Random, 95% CI) 0.13 [0.02, 0.98]
2.3 Nausea ‐ postoperative 7 601 Risk Ratio (M‐H, Random, 95% CI) 0.61 [0.48, 0.79]
2.3.1 Metoclopramide ‐ 10 mg 5 454 Risk Ratio (M‐H, Random, 95% CI) 0.63 [0.49, 0.80]
2.3.2 Metoclopramide ‐ 0.15 mg/kg 1 67 Risk Ratio (M‐H, Random, 95% CI) 0.40 [0.16, 1.02]
2.3.3 Droperidol ‐ 1.25 mg 1 80 Risk Ratio (M‐H, Random, 95% CI) 1.67 [0.43, 6.51]
2.4 Vomiting ‐ postoperative 9 860 Risk Ratio (M‐H, Random, 95% CI) 0.63 [0.44, 0.92]
2.4.1 Metoclopramide ‐ 10 mg 6 653 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.44, 1.20]
2.4.2 Metoclopramide ‐ 0.15 mg/kg 1 67 Risk Ratio (M‐H, Random, 95% CI) 0.32 [0.12, 0.90]
2.4.3 Droperidol ‐ 1.25 mg 2 140 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.32, 0.94]
2.5 'Nausea + vomiting' ‐ intraoperative (not pre‐specfied) 1 98 Risk Ratio (M‐H, Random, 95% CI) 0.12 [0.02, 0.88]
2.5.1 Metoclopramide ‐ 10 mg 1 98 Risk Ratio (M‐H, Random, 95% CI) 0.12 [0.02, 0.88]
2.6 'Nausea + vomiting' ‐ postoperative (not pre‐specified) 3 450 Risk Ratio (M‐H, Random, 95% CI) 0.23 [0.05, 1.02]
2.6.1 Metoclopramide ‐ 10 mg 3 360 Risk Ratio (M‐H, Random, 95% CI) 0.20 [0.02, 1.71]
2.6.2 Droperidol ‐ 0.625 mg 1 90 Risk Ratio (M‐H, Random, 95% CI) 0.30 [0.12, 0.75]
2.7 Maternal satisfaction 1 102 Risk Ratio (M‐H, Random, 95% CI) 1.42 [0.91, 2.21]
2.7.1 Metoclopramide ‐ 10 mg 1 102 Risk Ratio (M‐H, Random, 95% CI) 1.42 [0.91, 2.21]
2.8 Anxiety 1 50 Risk Ratio (M‐H, Random, 95% CI) 4.00 [0.48, 33.33]
2.8.1 Metoclopramide ‐ 10 mg 1 50 Risk Ratio (M‐H, Random, 95% CI) 4.00 [0.48, 33.33]
2.9 Headache/dizziness 1 102 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 8.00]
2.9.1 Metoclopramide ‐ 10 mg 1 102 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 8.00]
2.10 Hypotension 6 563 Risk Ratio (M‐H, Random, 95% CI) 1.08 [0.90, 1.30]
2.10.1 Metoclopramide ‐ 10 mg 4 278 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.77, 1.28]
2.10.2 Metoclopramide ‐ 0.15 mg/kg 1 67 Risk Ratio (M‐H, Random, 95% CI) 1.62 [0.66, 3.95]
2.10.3 Droperidol ‐ 0.5 mg 1 128 Risk Ratio (M‐H, Random, 95% CI) 1.13 [0.80, 1.60]
2.10.4 Droperidol ‐ 0.625 mg 1 90 Risk Ratio (M‐H, Random, 95% CI) 1.25 [0.69, 2.25]
2.11 Rescue antiemetics (not pre‐specified) 1 98 Risk Ratio (M‐H, Random, 95% CI) 0.26 [0.03, 2.25]
2.12 Sedation 2 220 Risk Ratio (M‐H, Random, 95% CI) 5.54 [2.78, 11.06]
2.12.1 Metoclopramide ‐ 10 mg 2 130 Risk Ratio (M‐H, Random, 95% CI) 4.24 [1.73, 10.41]
2.12.2 Droperidol ‐ 0.625 mg 1 90 Risk Ratio (M‐H, Random, 95% CI) 8.17 [2.77, 24.05]
2.13 Pruritus/itching 3 504 Risk Ratio (M‐H, Random, 95% CI) 0.98 [0.93, 1.03]
2.13.1 Metoclopramide ‐ 10 mg 2 429 Risk Ratio (M‐H, Random, 95% CI) 0.98 [0.93, 1.03]
2.13.2 Droperidol ‐ 1.25 mg 1 75 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.55, 1.53]