Comparison 7. Opioid antagonist/partial agonist vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
7.1 Nausea ‐ intraoperative	0	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
7.2 Vomiting ‐ intraoperative	0	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
7.3 Nausea ‐ postoperative	1	120	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.39, 1.45]
7.3.1 Nalbuphine ‐ 4 mg	1	120	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.39, 1.45]
7.4 Vomiting ‐ postoperative	1	120	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.35, 4.43]
7.4.1 Nalbuphine ‐ 4 mg	1	120	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.35, 4.43]
7.5 'Nausea + vomiting' ‐ intraoperative (not pre‐specified)	0	0	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
7.6 'Nausea + vomiting' ‐ postoperative (not pre‐specified)	1	77	Risk Ratio (M‐H, Random, 95% CI)	0.09 [0.02, 0.37]
7.6.1 Nalbuphine ‐ 0.5 mg	1	77	Risk Ratio (M‐H, Random, 95% CI)	0.09 [0.02, 0.37]
7.7 Pruritus/itching	2	197	Risk Ratio (M‐H, Random, 95% CI)	0.34 [0.02, 5.27]
7.7.1 Nalbuphine ‐ 0.5 mg	1	77	Risk Ratio (M‐H, Random, 95% CI)	0.13 [0.04, 0.39]
7.7.2 Nalbuphine ‐ 4 mg	1	120	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.74, 0.99]