Khalayleh 2005.

Study characteristics
Methods	RCT
Participants	Incluson criteria: Women having elective CS under spinal anaesthesia N = 150 women randomised, 147 were analysed but we only used data from 2 groups so we analysed data on 98 women Excluson criteria:
Interventions	Intervention 1: opioid ‐ excluded from the review Fentanyl ‐ 20 mcg IT ‐ not included in this review because it is an opioid N = 49 Intervention 2: dopamine antagonist (Comparison 2) Metoclopramide 10 mg IV N = 48 Comparator: placebo saline N = 50
Outcomes	intraoperative and PONV, rescue droperidol
Notes	Setting: Iran Dates: Jan 2002‐Dec 2003 Funding source: not reported Declaration of Interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	As above
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "intraoperative and post operative emetic episodes were recorded by doctor who had no knowledge of which study drug the patient had received"
Incomplete outcome data (attrition bias) All outcomes	Low risk	3 patients lost out of 150
Selective reporting (reporting bias)	Unclear risk	They report no side effects in results (but do not specify which side effects), also do not mention side effects in the methods
Other bias	Unclear risk	The fact the timing of the interventions are not clear in the Methods raises the risk of other biases