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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Mukherjee 2006.

Study characteristics
Methods RCT
Participants 80 ASA 1‐2, age 20‐34, undergoing CS under spinal anaesthesia, with no antiemetic drugs within 24 hours.
Interventions Intervention 1: sedative (Comparison 6)
  • Propofol at 0.5 mg/kg/hr.

  • N = 20.


Intervention 2: sedative (Comparison 6)
  • Propofol at 1.0 mg/kg/hr.

  • N = 20.


Intervention 3: sedative (Comparison 6)
  • Propofol at 1.5 mg/kg/hr.

  • N = 20.


Comparison: placebo
  • Continuous infusion of 10% intralipid.

  • N = 20.

Outcomes Intraoperative nausea, vomiting, retching, adverse events.
Notes Setting: Calcutta National Medical College and Hospital, Kolkata, India.
Dates: not reported
Funding source: not reported.
Declaration of interest: not reported.
Retching combined with vomiting, dosage groups combined to yield overall treatment effect.
Drugs are in separate subgroups but then pooled in our analysis, so the placebo data are dealt with according to our methods (Unit of analysis issues).
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation chart.
Allocation concealment (selection bias) Unclear risk Identical syringes prepared by uninvolved anaesthetist.
Blinding of participants and personnel (performance bias)
All outcomes Low risk Quote: "Double blinded manner".
Blinding of outcome assessment (detection bias)
All outcomes Low risk Outcomes assessed by anaesthetist unaware of allocation.
Incomplete outcome data (attrition bias)
All outcomes Low risk No loss of participants.
Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol.
Other bias Low risk No differences in baseline groups.