Mukherjee 2006.
Study characteristics | ||
Methods | RCT | |
Participants | 80 ASA 1‐2, age 20‐34, undergoing CS under spinal anaesthesia, with no antiemetic drugs within 24 hours. | |
Interventions | Intervention 1: sedative (Comparison 6)
Intervention 2: sedative (Comparison 6)
Intervention 3: sedative (Comparison 6)
Comparison: placebo
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Outcomes | Intraoperative nausea, vomiting, retching, adverse events. | |
Notes | Setting: Calcutta National Medical College and Hospital, Kolkata, India. Dates: not reported Funding source: not reported. Declaration of interest: not reported. Retching combined with vomiting, dosage groups combined to yield overall treatment effect. Drugs are in separate subgroups but then pooled in our analysis, so the placebo data are dealt with according to our methods (Unit of analysis issues). |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated randomisation chart. |
Allocation concealment (selection bias) | Unclear risk | Identical syringes prepared by uninvolved anaesthetist. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Quote: "Double blinded manner". |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Outcomes assessed by anaesthetist unaware of allocation. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss of participants. |
Selective reporting (reporting bias) | Unclear risk | We did not assess the trial protocol. |
Other bias | Low risk | No differences in baseline groups. |