Skip to main content
. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Rasooli 2014.

Study characteristics
Methods RCT
Participants Inclusiom criteria:
  • Women for elective CS under spinal anaesthesia

  • ASA 1 or 2, 20–30 years

  • N = 90


Exclusion criteria:
Interventions Intervention 1: sedative (Comparison 6)
  • Propofol 20 mg + 1 mg/kg/hr.

  • bolus and infusion, after cord clamping

  • N = 30.


Intervention 2: sedative (Comparison 6)
  • Midazolam 1 mg + 1.0 mg/kg/hour

  • bolus infusion after cord clamping

  • N = 30


Comparison: placebo
  • Bolus + infusion of saline.

  • N = 30.

Outcomes nausea and vomiting and retching on 4‐point score
Notes Setting: Al‐Zahra Obstetrics and Gynecology Educational Hospital, Tabriz, Iran.
Dates: not reported.
Funding source: not reported.
Declaration of interest: not reported.
Looks like N&V only examined intra‐op. Authors do not state if post‐op N&V specifically looked at.
Drugs are in separate subgroups but then pooled in our analysis, so the placebo data are dealt with according to our methods (Unit of analysis issues)
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Unspecified: quote: "randomly allocated"
Allocation concealment (selection bias) Unclear risk Solutions were prepared by an assistant not involved in care
Blinding of participants and personnel (performance bias)
All outcomes High risk Quote: "Double blind". However patients could see what infusion they were receiving (propofol)
Blinding of outcome assessment (detection bias)
All outcomes Low risk Assessments by blinded third party
Incomplete outcome data (attrition bias)
All outcomes Low risk None
Selective reporting (reporting bias) Unclear risk Specified endpoints; possibly low risk?
Other bias Unclear risk VAS scores apparently taken but not reported