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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Rudra 2004a.

Study characteristics
Methods RCT
Participants 60 ASA 1‐2 women scheduled for CS with spinal anaesthesia, no GI/liver/ear disease, hyperemesis, hyperlipidaemia, antiemetics within 24 hours.
Interventions Intervention: sedative (Comparison 6)
  • Propofol 1 mg/kg/hour infusion.

  • N = 30.


Comparison: placebo
  • 10% intralipid infusion.

  • N = 30.

Outcomes Nausea, retching, vomiting, rescue antiemetics.
Notes Setting: Calcutta National Medical College, Kolkata, India.
Dates: not reported.
Funding source: not reported.
Declaration of interest: not reported.
Retching data combined with vomiting.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation.
Allocation concealment (selection bias) Unclear risk Not described.
Blinding of participants and personnel (performance bias)
All outcomes High risk Treating anaesthetist not blinded.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not described.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Not described.
Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol.
Other bias Unclear risk No major differences in baseline characteristics.