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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Shen 2012.

Study characteristics
Methods RCT.
Participants Incluson criteria:
  • Women undergoing elective CS

  • N = 260 randomised, no exclusions but we will only use the data from 3 of the groups as our review does not include combination drugs so 195 in the analysis


Exclusion criteria:
Interventions Intervention 1: anticholinergic (Comparison 5)
  • Scopolamine 0.3 mg/5 mL IV

  • N = 65


Intervention 2: 5HT3 antagonist (Comparison 1)
  • Ondansetron 4 mg IV

  • N = 65


Intervention 3: anticholinergic + 5HT3 antagonist ‐ exclude as a combination of drugs
  • Scopolamine+ondansetron

  • N = 65


Comparator: placebo
  • N = 65

Outcomes Nausea and vomiting
Notes Setting: not reported but authors from China‐Japan Frienship Hospital, Beijing, China
Dates: not reported
Funding source: not reported.
Declaration of interest: not reported.
English abstract only assessed, we will attempt to locate the full paper in English.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Only reported as “…randomly divided…”
Allocation concealment (selection bias) Unclear risk Not reported in abstract
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not reported in abstract
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported in abstract
Incomplete outcome data (attrition bias)
All outcomes Low risk Seems clear that all participants provided data (e.g.. in table 3 the percentages are in brackets)
Selective reporting (reporting bias) Unclear risk Not possible to assess as we only have the English abstract at this point
Other bias Unclear risk Not possible to assess as we only have the English abstract at this point