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. 2021 May 18;2021(5):CD007579. doi: 10.1002/14651858.CD007579.pub3

Wu 2007.

Study characteristics
Methods Individual RCT
Participants Inclusion criteria:
  • Women undergoing elective CS under spinal anaesthesia. Contraindications including if regional anaesthesia contraindicated; allergy to dexamethasone, droperidol, opioids, local anaesthetics; established hypertension; or glucose intolerance; GI disease; administration of antiemetic in previous 24 hours.

  • N = 120 women randomised, none were excluded after randomisation but we only used 3 groups in our analysis so we analysed data from 90 women.


Exclusion criteria:
Interventions Group 1: steroid (Comparison 3)
  • Dexamethasone 8 mg.

  • N = 30.


Group 2: dopamine antagonist (Comparison 2)
  • Droperidol 1.25 mg.

  • N = 30.


Group 3: steroid + Dopamine antagonistdata nor used in this review
  • Dexamethasone 4 mg + Droperidol 0.625 mg.

  • N = 30.


Group 4: Comparison: placebo
  • Normal saline.

  • N = 30.

Outcomes Composite outcome of nausea and vomiting
Notes Setting: Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Dates: not reported.
Funding source: not reported.
Declaration of interest: not reported.
Only useable data are postoperative vomiting. Other outcomes are amalgamated in composite score. We have written to the authors and attempt to get separated data.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "computer generated random numbers."
Allocation concealment (selection bias) Unclear risk No details.
Blinding of participants and personnel (performance bias)
All outcomes Low risk Medications made up by uninvolved anaesthetist blinded to treatment
Blinding of outcome assessment (detection bias)
All outcomes Low risk Observers blinded to allocations.
Incomplete outcome data (attrition bias)
All outcomes Low risk No loss to follow‐up, ITT analysis.
Selective reporting (reporting bias) Unclear risk We did not assess the trial protocol.
Other bias Low risk No baseline imbalance.