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. Author manuscript; available in PMC: 2021 May 18.
Published in final edited form as: Exp Cell Res. 2018 Dec 21;375(2):106–112. doi: 10.1016/j.yexcr.2018.12.012

Fig. 3. The caspase inhibitor Q-VD-OPh prevents apoptosis mediated by the combination of romidepsin with CTZ or BIF.

Fig. 3.

HCT-116 and A549 cells were treated with romidepsin (RD) alone or in combination with 25 μM clotrimazole (CTZ) or bifonazole (BIF) as outlined in Fig. 1A in the presence of absence of 25 μM of the pan-caspase inhibitor Q-VD-OPh. Cells were harvested and stained with annexin V/SYTOX green and assayed by flow cytometry as outlined in Materials and Methods. Percent annexin positive cells determined from at least 3 independent experiments are summarized in the graph. Significance (p values) is shown for the bracketed conditions.