Table 4.
CFP-10pep specificity in subgroups of the unlikely TB population
| Unlikely TB | Total | HIV-infected | HIV-uninfected | |||
|---|---|---|---|---|---|---|
| CFP-10 (pos./total) | Specificity % (95%CI) | CFP-10 (pos./total) | Specificity % (95%CI) | CFP-10 (pos./total) | Specificity % (95%CI) | |
| NTM infection | 2/14 | 85.7 (57.2–98.2) | 1/12 | 91.7 (61.5–99.8) | 1/2 | 50.0 (1.3–98.7) |
| Other infections* | 13/153 | 91.5 (85.9–95.4) | 11/88 | 87.5 (78.7–93.6) | 2/65 | 96.9 (89.3–99.6) |
| Other inflammatory diseases | 7/148 | 95.3 (90.5–98.1) | 3/63 | 95.2 (86.7–99.0) | 4/85 | 95.3 (88.4–98.7) |
| Other diseases | 0/35 | 100 (90.0–100) | 0/28 | 100 (87.7–100) | 0/7 | 100 (59.0–100) |
| Latent TB infection | 5/44 | 88.6 (75.4–96.2) | 3/25 | 88.0 (68.8–97.5) | 2/19 | 89.5 (66.9–98.7) |
| No disease (healthy) | 1/45 | 97.8 (88.2–99.9) | 1/27 | 96.3 (81.0–99.9) | 0/18 | 100 (81.5–100) |
| Unclear diagnosis | 0/5 | 100 (47.8–100) | 0/1 | 100 (2.5–100) | 0/4 | 100 (39.8–100) |
| Total | 22/402# | 94.5 (91.8–96.5) | 15/218 | 93.1 (88.9–96.1) | 7/184 | 96.2 (92.3–98.5) |
*Bacterial, viral, fungal, and other infections
#Several children had co-infections, including 7 with non-tuberculous mycobacterium (NTM) infections and 12 with latent TB infections, while 23 children with latent TB infections also had an unrelated inflammatory disease