Table 5.
TB diagnostic performance of CFP-10pep, smear, culture, and TST
| Comparison | Participantsa | CFP-10 Sensitivity | 2nd assay Sensitivity | p valueb | CFP-10 Specificity | 2nd assay Specificity | p value | CFP-10 Accuracy | 2nd assay Accuracy | p value |
|---|---|---|---|---|---|---|---|---|---|---|
| CFP-10pep vs X-ray | 183 | 82.3% (81.9–82.7) | 88.2% (87.9–88.5) | 0.346 | 85.2% (85.0–85.4) | 74.7% (74.4–75.1) | 0.019 | 84.1% (84.0–84.2) | 79.7% (79.6–79.9) | 0.015 |
| CFP-10pep vs smear | 140 | 85.9% (85.5–86.3) | 15.6% (15.2–16.0) | < 0.001 | 80.2% (79.8–80.6) | 89.4% (89.2–89.7) | 0.127 | 82.8% (82.6–83.0) | 55.7% (55.3–56.0) | < 0.001 |
| CFP-10pep vs culture | 136 | 88.3% (87.9–88.6) | 11.6% (11.3–12.0) | < 0.001 | 80.2% (79.8–80.6) | 100% (95.3–100) | < 0.001 | 83.8% (83.6–84.0) | 61.0% (60.6–61.37) | < 0.001 |
| CFP-10pep vs TST | 377 | 81.8% (81.3–82.2) | 68.1% (67.5–68.8) | 0.083 | 93.8% (93.8–93.9) | 82.9% (82.8–83.0) | < 0.001 | 91.7% (91.7–91.8) | 80.3% (80.2–80.4) | 0.007 |
The results listed in this Table indicate percent diagnostic sensitivity, specificity and accuracy with an estimated 95% CI adjusted for sample size
aParticipants who were conducted both CFP-10pep assay and secondary assay (X-ray, smear, culture, and TST, respectively)
bListed p values indicate the probability for a significant difference between the diagnostic sensitivity, specificity, or accuracy of CFP-10 and the test listed in the first column of the matching row by McNemar’s test