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. 2021 May 17;16:7. doi: 10.1186/s12263-021-00688-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Impact of BBP supplementation on blood metabolite levels. Volcano plot of paired comparisons between metabolite blood levels in pre- and post-supplementation groups. On the x-axis, a count of significant sample pairs is shown. On the y-axis, the minus logarithm of paired t test P values is shown. Blood levels of a given metabolite were considered significantly different between pre- and post-supplementation states when the paired t test P value was < 0.05, the change in metabolite blood levels was higher than 25% (> 1.25-fold change), and the count of significant pairs was higher than the 50% of the total count of pairs. Each dot represents a metabolite. Metabolites showing statistically significant changes following the blueberry supplementation are depicted as blue dots on the right (increase) and left (decrease) top corners. Top-ten significantly different metabolites are labelled. Orn ornithine, DG diacylglycerol, Cer ceramide, Ind-SO4 indoxyl sulfate, TG triglyceride, HipAcid hippuric acid