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. 2021 May 17;19:142. doi: 10.1186/s12951-021-00880-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Characterizations of HA-PDA@IQ/DOX NPs. a Typical TEM images, Scale bar: 200 nm. b Particle size distribution, c Surface zeta potential, d In vitro stability, e FETEM images and elemental mapping images (Mn, C, N, and O), Scale bar:100 nm, f XRD spectra, g XPS spectra of HA-PDA@IQ/DOX NPs. h Peak-fitting spectra for Mn2p, i C1s, j O1s, k N1s of HA-PDA@IQ/DOX NPs