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. 2021 May 17;19:142. doi: 10.1186/s12951-021-00880-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — In vitro photothermal performance of HA-PDA@IQ/DOX NPs. a Diagram of the photothermal effect of HA-PDA@IQ/DOX NPs. b Vis–NIR absorbance spectra of HA-PDA@IQ/DOX. c Photothermal heating curves of HA-PDA@IQ/DOX at different concentrations and d under varied power densities. e Thermal imaging of HA-PDA@IQ/DOX NPs solution under different laser power density. f Periodical temperature changes of the HA-PDA@IQ/DOX NPs solution upon laser irradiation for five laser on/off cycles and g following Vis–NIR absorbance spectra. h Photothermal response of HA-PDA@IQ/DOX NPs solution treated with an NIR laser (808 nm, 2 W/cm²) for 600 s and left to cool down. i Linear time data versus − ln θ obtained from the cooling stage