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. 2020 Dec 14;24(5):367–382. doi: 10.1093/ijnp/pyaa097

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Mechanisms that underlie the association between schizophrenia and type 2 diabetes mellitus (T2DM). The mechanisms of the increasing prevalence of T2DM in patients with schizophrenia are multifactorial. Poor diet and sedentary lifestyle are included in the traditional risk factors. Iatrogenic risk during treatment with antipsychotics is included in risk factors unique to schizophrenia (Ward and Druss, 2015). Accumulating evidence suggests shared genetic susceptibility and biological common pathway of both schizophrenia and T2DM.