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. 2021 May 17;19:141. doi: 10.1186/s12951-021-00879-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Que/mAb GAP43-Exo enhanced the stability and solubility of Que in vitro. a The UV absorption curve of Que and exosomal Que in PBS and plasma. b The remaining ratio (RR) of Que and exosomal Que in PBS and plasma. Data are expressed as means ± SD (n = 3), *P < 0.05. c Tissue distributions of Que in rats treated with Que and Que/mAb GAP43-Exo at 8 h after single i.v. administration. The accumulation ratio was quantified by comparing the concentrations of exosomal Que in different organs with the concentration of free Que in organs. The accumulation ratio of free Que in organs was set as 1.0. Data are expressed as means ± SD (n = 3), *P < 0.05