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. 2021 May 17;13:112. doi: 10.1186/s13148-021-01096-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The correlation between NEFM transcriptional expression and DNA methylation of NEFM in TCGA BRCA cohort. a NEFM transcriptional expression was downregulated in BRCA compared with normal breast tissue. b–d NEFM DNA methylation was enhanced in BRCA compared with normal breast tissue (b NEFMmet = mean beta value of NEFM DNA methylation using 24 probe of HumanMethylation450K platform and 2 probe of HumanMethylation27K; c NEFMmet = mean beta value of NEFM DNA methylation of HumanMethylation450K platform; d NEFMmet = mean beta value of NEFM DNA methylation of HumanMethylation27K platform). e–g Significant higher DNA methyltransferase was connected with NEFM low expression. e DNMT1 median expression 12.65 vs. 12.45 in NEFM low vs. high-expression group, p < 0.001; f DNMT3A median expression 11.57 vs. 11.41 in NEFM low vs. high-expression group, p < 0.001; g DNMT1 median expression 9.33 vs. 8.97 in NEFM low- vs. high-expression group, p < 0.001). h–j. DNA methylation of NEFM inversely correlated with NEFM expression. h NEFMmet = log2 mean beta value of NEFM DNA methylation of 24 probe of HumanMethylation450K platform, HR = − 0.21, p = 3.9e−09; i NEFMmet = log2 beta value of cg17078116 probe, HR = − 0.29, p < 2.2e−16; j NEFMmet = log2 beta value of cg26980244 probe, HR = − 0.30, p < 2.2e−16