Table 3.

Univariable Cox proportional hazards regression survival analyses of different NEFM DNA methylation loci in TCGA BRCA HumanMethylation450K platform

VarNames	UCSC_RefGene_Group	Relation_to_UCSC_CpG_Island	HR	CI95	p
NEFMmet			1.6	1.03–2.48	0.036
cg01583969	5'UTR;Body	S_Shore	1.47	0.95–2.28	0.086
cg02002551	5'UTR;Body	S_Shore	1.14	0.74–1.76	0.545
cg02106941	TSS1500;1stExon	Island	0.97	0.63–1.49	0.888
cg02761376	TSS1500;1stExon	Island	1.56	1.01–2.42	0.045
cg03012544	Body;Body	S_Shore	1.14	0.74–1.75	0.555
cg03169018	TSS200;Body	Island	1.2	0.78–1.84	0.412
cg04118306	TSS200;1stExon	Island	0.97	0.63–1.49	0.885
cg07502389	TSS200;TSS1500	Island	1.76	1.14–2.74	0.012
cg07552803	TSS1500;1stExon	Island	1.31	0.85–2.02	0.216
cg09234518	TSS200;TSS1500	Island	1.96	1.25–3.07	0.003
cg12026749	5'UTR;Body	S_Shore	1.24	0.8–1.9	0.335
cg13387869	3'UTR;3'UTR	S_Shelf	0.84	0.55–1.29	0.424
cg16459364	TSS200;TSS1500	Island	1.14	0.74–1.76	0.557
cg17078116	TSS200;1stExon	Island	1.11	0.72–1.7	0.647
cg18267374	TSS1500;5'UTR;1stExon	Island	1.75	1.13–2.72	0.013
cg18898125	TSS1500	N_Shore	1.22	0.79–1.87	0.368
cg19677607	TSS200;1stExon	Island	1.6	1.03–2.48	0.038
cg20585869	TSS200;1stExon	Island	0.78	0.5–1.2	0.261
cg22562942	TSS200;1stExon	Island	1.35	0.87–2.1	0.181
cg23290344	TSS1500;1stExon	Island	1.34	0.87–2.06	0.188
cg24705551	Body;Body	S_Shelf	1.12	0.73–1.72	0.596
cg26330518	TSS1500	N_Shore	1.56	1.01–2.41	0.044
cg26980244	5'UTR;1stExon;Body	Island	1.42	0.92–2.19	0.116
cg27475652	Body;Body	S_Shelf	1.04	0.67–1.6	0.867

HR: hazard ratio; CI 95: 95% confidence interval. Significant p Values < 0.05 are in bold. NEFMmet: mean beta value of all DNA methylation loci of NEFM. Seven DNA methylation loci of NEFM including NEFMmet were connected with survival