Table 4.
Correlation of NEFM transcriptional expression/DNA methylation with immunomodulators based on TISIDB and TCGA database
| Immunomodulators | NEFM expression | NEFM DNA methylation | ||
|---|---|---|---|---|
| TISIDB rho, n=1100 (TCGA R, n = 808) |
p | TISIDB rho, n=785 (TCGA R, n = 808) |
P | |
| ADORA2A | 0.137 (0.15) | 5.07e−6 (2.5e−05) | − 0.095 (− 0.004) | 0.00751 (0.26) |
| BTLA | 0.032 (0.041) | 0.296 (0.240) | − 0.477 (− 0.35) | 2.2e−16 |
| CD160 | − 0.019 (0.07) | 0.539 (0.046) | − 0.157 (− 0.15) | 9.61e−06 (1.5e−05) |
| CD244 | 0.06 (0.076) | 0.0467 (0.032) | − 0.525 (− 0.35) | < 2.2e−16 |
| CD274(PD-L1) | − 0.006 (0.038) | 0.854 (0.28) | − 0.304 (− 0.28) | 4.23e−18 (2.3e−15) |
| CD96 | 0.037 (0.042) | 0.226 (0.23) | − 0.479 (− 0.34) | < 2.2e−16 |
| CSF1R | 0.132 (0.11) | 0.22e−05 (0.0027) | − 0.44 (− 0.34) | < 2.2e−16 |
| CTLA4 | − 0.028 (0.00073) | 0.357 (0.98) | − 0.432 (0.3) | < 2.2e−16 |
| HAVCR2 | 0.008 (− 0.0079) | 0.789 (0.82) | − 0.298 (− 0.21) | 2.16e−17 (1.8e−09) |
| IDO1 | − 0.112 (− 0.1) | 0.000203 (0.0036) | − 0.384 (− 0.26) | < 2.2e−16 (1.2e−13) |
| IL10 | − 0.003 (− 0.025) | 0.921 (0.48) | − 0.388 (− 0.29) | < 2.2e−16 |
| IL10RB | − 0.08 (− 0.036) | 0.00821 (0.31) | − 0.262 (− 0.2) | 1.08e−13 (1.3e−08) |
| KDR(VEGFR) | 0.127 (0.11) | 2.51e−05 (0.0017) | − 0.117 (− 0.15) | 0.000984 (2.9e−05) |
| LAG3 | − 0.171 (− 0.14) | 1.11e−08 (4.5e−05) | − 0.314 (− 0.2) | 2.38e−19 (6.9e−09) |
| LGALS9 | − 0.051 (− 0.059) | 0.0912 (0.093) | − 0.293 (− 0.17) | 9.15e−17 (1.2e−06) |
| PDCD1 | 0.007 (0.023) | 0.816 (0.51) | − 0.43 (− 0.29) | < 2.2e−16 |
| PDCD1LG2 | 0.066 (0.076) | 0.0281 (0.031) | − 0.476 (− 0.34) | < 2.2e−16 |
| PVRL2(NECTIN2) | 0.027 (0.045) | 0.378 (0.2) | 0.32 (0.14) | 2.9e−20 (9.9e−05) |
| TGFB1 | 0.32 (0.3) | < 2.2e−16 | − 0.28 (− 0.2)3) | 1.91e−15 (3.6e−11) |
| TGFBR1 | 0.214 (0.21) | 9.26e−13 (2.7e−09) | − 0.178 (− 0.13) | 5.46e−07 (0.00014) |
| TGFBR2 | (0.35) | < 2.2e−16 | (− 0.33) | < 2.2e−16 |
| TIGIT | − 0.02 (− 0.0034) | 0.509 (0.92) | − 0.446 (− 0.31) | < 2.2e−16 |
| VTCN1 | 0.207 (0.21) | 4.34e−12 (2.4e−09) | − 0.175 (− 0.07) | 8.63e−07 (0.048) |
| C10orf54(VSIR, VISTA) | 0.205 (0.18) | 7.97e−12 (2.3e−07) | − 0.552 (− 0.39) | < 2.2e−16 |
| CD27(TNFRSF7) | 0.097 ( (0.11) | 0.00121 (0.0013) | − 0.452 (− 0.31) | < 2.2e−16 |
| CD276 | 0.168 (0.19) | 2.12e−08 (9.7e−08) | − 0.038 (− 0.065) | 0.284 (0.068) |
| CD28 | 0.042 (0.038) | 0.16 (0.28) | − 0.458 (− 0.33) | < 2.2e−16 |
| CD40 | 0.137 (0.15) | 5.1e−06 (2.2e−05) | − 0.553 (− 0.38) | < 2.2e−16 |
| CD40LG | 0.088 (0.093) | 0.00346 (0.0081) | − 0.457 (0.32) | < 2.2e−16 |
| CD48 | 0.062 (0.062) | 0.0391 (0.079) | − 0.458 (− 0.31) | < 2.2e−16 |
| CD70 | 0.108 (0.11) | 0.000345 (0.0017) | − 0.312 (− 0.17) | 3.39e−19 (1.4e−06) |
| CD80 | − 0.069 | 0.0228 | − 0.259 (− 0.18) | 1.95e−13 (2.8e−07) |
| CD86 | − 0.028 (− 0.056) | 0.357 (0.11) | − 0.375 | < 2.2e−16 |
| CXCL12 | 0.467 (0.43) | < 2.2e−16 | − 0.32 (− 0.2) | 3.31e−20 (1.5e−08) |
| CXCR4 | 0.053 (0.087) | 0.0763(0.013) | − 0.313 (− 0.17) | 3.11e−19 (8.2e−07) |
| ENTPD1(CD39) | 0.267 (0.3) | 2.85e−19 (< 2.2e−16) | − 0.271 (− 0.23) | 1.46e−14 (5.5e−11) |
| ICOS | − 0.064 (− 0.044) | 0.0341 (0.21) | − 0.42 (− 0.29) | < 2.2e−16 |
| ICOSLG | 0.045 (0.0042) | 0.15 (0.91) | − 0.193 (− 0.027) | 5.69e−08 (0.44) |
| IL2RA | − 0.033 (− 0.022) | 0.276 (0.53) | − 0.454 (− 0.33) | < 2.2e−16 |
| IL6 | 0.091 (0.087) | 0.00266 (0.014) | − 0.425 (− 0.3) | < 2.2e−16 |
| IL6R | − 0.012 (− 0.015) | 0.7 (0.67) | − 0.341 (− 0.29) | < 2.2e−16 |
| KLRC1 | 0.004 (0.017) | 0.907 (0.64) | − 0.386 (− 0.28) | < 2.2e−16 (2.7e−16) |
| KLRK1 | 0.041 (0.075) | 0.171 (0.033) | − 0.456 (− 0.28) | < 2.2e−16 (4.3e−16) |
| LTA | − 0.033 (− 0.015) | 0.273 (0.66) | − 0.413 (− 0.28) | < 2.2e−16 (1e−15) |
| MICB | 0.003 (− 0.0094) | 0.93 (0.79) | − 0.047 (− 0.16) | 0.186(3e−06) |
| NT5E(CD73) | 0.224 (0.2) | 6.85e−14 (1e−08) | − 0.306 (− 0.28) | 2.26e−18 (5.6e−16) |
| PVR | − 0.204 (− 0.17) | 1.05e−11 (8.9e−07) | − 0.134 (− 0.11) | 0.00017 (0.0019) |
| RAET1E | 0.094 (0.12) | 0.00182 (0.00065) | − 0.073 (− 0.016) | 0.0411 (0.65) |
| TMEM173(STING) | 0.231 (0.2) | 1.14e−14 (6.5e−09) | − 0.263 (− 0.19) | 9.54e−14 (1.1e−07) |
| TNFRSF13B | 0.202 (0.21) | 1.39e−11 (3.8e−09) | − 0.419 (− 0.31) | < 2.2e−16 |
| TNFRSF13C | 0.068 (0.027) | 0.0237 (0.44) | − 0.346 (− 0.26) | < 2.2e−16 (4.6e−14) |
| TNFRSF14 | 0.048 (0.055) | 0.109 (0.12) | − 0.074 (0.044) | 0.0377 (0.21) |
| TNFRSF17 | 0.113 (0.13) | 0.000181(0.00037) | − 0.396 (− 0.27) | < 2.2e−16 (3.9e−15) |
| TNFRSF18 | − 0.029 (− 0.04) | 0.335 (0.25) | 0.064 (− 0.021) | 0.0727 (0.00037) |
| TNFRSF25 | 0.014 (0.078) | 0.646 (0.028) | − 0.257 (− 0.14) | 3.01e−13 (4.3e−05) |
| TNFRSF4 | 0.082 (0.082) | 0.00664 (0.019) | − 0.281 (− 0.18) | 1.51e−15 (2.9e−07) |
| TNFRSF8 | 0.086 (0.085) | 0.00424 (0.015) | − 0.529 (− 0.37) | < 2.2e−16 |
| TNFRSF9 | 0.03 (0.036) | 0.319 (0.3) | − 0.443 (− 0.36) | < 2.2e−16 |
| TNFSF13 | − 0.015 (0.028) | 0.617 (0.42) | 0.047 (0.075) | 0.189 (0.035) |
| TNFSF13B | − 0.015 (− 0.025) | 0.623 (0.48) | − 0.343 (− 0.25) | < 2.2e−16 (1.3e−12) |
| TNFSF14 | 0.082 (0.084) | 0.00622 (0.017) | − 0.45 (− 0.32) | < 2.2e−16 |
| TNFSF15 | 0.095 (0.085) | 0.00153 (0.015) | − 0.201 (− 0.12) | 1.36e−08 (0.00091) |
| TNFSF4 | 0.149 (0.17) | 6.77e−07 (2.1e−06) | − 0.081 (− 0.096) | 0.0228 (0.0064) |
| TNFSF9 | 0.024 (0.086) | 0.00165 (0.015) | − 0.256 (− 0.11) | 3.82e−13 (0.0012) |
| ULBP1 (NKG2D) | − 0.029 (0.0054) | 0.333 (0.88) | − 0.159 (− 0.015) | 7.37e−06 (0.68) |
Significant p value < 0.05 is in bold