Table 2.
Natural product of the epigenetic target and clinical trials
| Natural product | Epigenetic target | Condition | References | Clinical trial (Condition) |
|---|---|---|---|---|
| Resveratrol | DNMT | Breast cancer | 95 |
NCT00256334 (Colon Cancer) NCT00433576 (Colon Cancer) |
| Curcumin |
DNMT EZH2 |
Prostate cancer Lung cancer |
96–99 |
NCT03211104 (Prostate cancer) NCT01333917 (Colon Cancer) NCT02439385 (Colon Cancer) NCT01160302 (Head and Neck Cancer) NCT01042938 (Breast cancer) NCT00113841 (Multiple Myeloma) |
| Sulforaphane | EZH2 | Melanoma | 100 |
NCT01228084 (Prostate cancer) NCT00946309 (Prostate cancer) NCT00894712 (Breast cancer) NCT00982319 (Breast cancer) |
| Tanshindiols | EZH2 | B cell lymphoma | 101 | No studies |
| Rottlerin | EZH2 | Prostate cancer | 102 | No studies |
| Olive oil | HDAC | Multiple Myeloma | 103 | NCT02599103 (Colorectal Neoplasms) |
| Ibotenic acid | HDAC7 | Breast cancer | 104 | No studies |
| Baicalein | HDAC | Core binding factor-acute myeloid leukemia | 105 | No studies |