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. 2021 May 17;14:80. doi: 10.1186/s13045-021-01089-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Association of postoperative and post-adjuvant chemotherapy ctDNA status with recurrence risk. a Kaplan–Meier estimates of recurrence-free survival (RFS) according to ctDNA status at day 3–7 postoperatively. b The nomogram constructed by selected clinicopathological factors, recurrent-mutated genes, and ctDNA status at day 3–7 postoperatively for predicting 1-year and 2-year RFS. Mut, mutant; Wt, wild-type. c The clinical courses together with ctDNA statuses of 17 out of 20 ctDNA-positive (at day 3–7 postoperation) patients who received adjuvant chemotherapy (ACT). d Kaplan–Meier curves of RFS of the 137 patients who had plasma samples drawn after ACT, stratified by ctDNA status at first sampling point post-ACT