Table 1.
Univariate and multivariate Cox analysis of recurrence-free survival by clinicopathological variables and ctDNA status at 3–7 days postoperation
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P* | HR (95% CI) | P* | |
| Age, years | ||||
| ≤ 60 versus > 60 | 1.44 (0.71–2.91) | 0.313 | ||
| Sex | ||||
| Male versus female | 0.74 (0.37–1.47) | 0.387 | ||
| Primary tumor location | ||||
| Right-sided versus left-sided | 1.87 (0.93–3.74) | 0.077 | ||
| Pathological stage | ||||
| III versus II | 2.26 (1.07–4.79) | 0.032 | 1.18 (0.50–2.77) | 0.706 |
| Lymphovascular invasion | ||||
| Yes versus no | 2.60 (1.30–5.22) | 0.007 | 1.53 (0.67–3.48) | 0.316 |
| Nerve invasion | ||||
| Yes versus no | 2.04 (1.02–4.08) | 0.045 | 1.99 (0.90–4.39) | 0.091 |
| Histological type | ||||
| Mucinous versus adenocarcinoma | 0.90 (0.27–2.94) | 0.856 | ||
| Histological grade | ||||
| Poor versus medium/well | 0.88 (0.38–2.03) | 0.757 | ||
| MSI status | ||||
| MSI-L/MSS versus MSI-H | 0.99 (0.30–3.24) | 0.984 | ||
| Preoperative ctDNA status | ||||
| Positive versus negative | 5.66 (1.72–18.57) | 0.004 | 3.79 (1.12–12.86) | 0.032 |
| ctDNA status at day 3–7 postoperation | ||||
| Positive versus negative | 10.98 (5.31–22.72) | < 0.001 | 8.02 (3.59–17.92) | < 0.001 |
*P value in bold denotes statistically significant