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. 2021 May 18;21:568. doi: 10.1186/s12885-021-08320-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Immune and Expression Signatures and Response to Neoadjuvant Chemotherapy and Survival in TNBC. a The calculated score for 125 published gene expression signatures for 127 patients with data on response to neoadjuvant chemothrapy and distant metastasis-free survival (DMFS). Each signature is a point. The association of each signature with neoadjuvant chemotherapy response (pathologic complete response vs. RD) by simple linear regression (y-axis) and hazard ratio for each signature using DMFS (x-axis) are displayed. Signatures were grouped by phenotype (as previously described [7]), identified by color: proliferation signatures (red), immune signatures (blue), ER/HER2 signatures (green), mesenchymal signatures (orange), others (grey). Size of each point relates to the hazard ratio p-value for each signature. b The association of three representative signatures from each group (immune, proliferation, ER/HER2, mesenchymal) with the relative proportion of 22 inferred immune cell subsets via CIBERSORT across all samples with gene expression data (n = 453) are visualized using CorrPlot [26, 29].