Table I.
KIR gene frequencies in male patients with alcoholic cirrhosis and healthy controls
| KIR genes* | P/A | Healthy controls (N = 319) n (%) | Alcoholiccirrhosis (AC) | P2 | P3 | P4 | |||
|---|---|---|---|---|---|---|---|---|---|
| Total AC patients (N = 281) n (%) | P1 | Non-viral (N = 213) n (%) | Viral (N = 68) n (%) | ||||||
| iKIRs: | |||||||||
| 2DL1 (S1-) | + | 197 (61.8) | 160 (56.9) | 0.244 | 115 (54.0) | 45 (66.2) | 0.088 | 0.581 | 0.092 |
| – | 122 (38.2) | 121 (43.1) | 98 (46.0) | 23 (33.8) | |||||
| 2DL2 | + | 202 (63.3) | 149 (53.0) | 0.013a | 112 (52.6) | 37 (54.4) | 0.015d | 0.173 | 0.889 |
| – | 117 (36.7) | 132 (47) | 101 (47.4) | 31 (45.6) | |||||
| 2DL3 | + | 279 (87.5) | 249 (88.6) | 0.707 | 190 (89.2) | 59 (86.8) | 0.586 | 0.842 | 0.661 |
| – | 40 (12.5) | 32 (11.4) | 23 (10.8) | 9 (13.2) | |||||
| 3DL1 | + | 304 (95.3) | 268 (95.4) | 1.000 | 201 (94.4) | 67 (98.5) | 0.689 | 0.325 | 0.200 |
| – | 15 (4.7) | 13 (4.6) | 12 (5.6) | 1 (1.5) | |||||
| 2DL5 | + | 170 (53.3) | 158 (56.2) | 0.511 | 121 (56.8) | 37 (54.4) | 0.477 | 0.894 | 0.780 |
| – | 149 (46.7) | 123 (43.8) | 92 (43.2) | 31 (45.6) | |||||
| aKIRs: | |||||||||
| 2DS1 (L1+) | + | 119 (37.3) | 119 (42.3) | 0.211 | 96 (45.1) | 23 (33.8) | 0.087 | 0.678 | 0.121 |
| – | 200 (62.7) | 162 (57.7) | 117 (54.9) | 45 (66.2) | |||||
| 2DS2 (L2+) | + | 201 (63.0) | 146 (52) | 0.006b | 109 (51.2) | 37 (54.4) | 0.007e | 0.217 | 0.677 |
| – | 118 (37.0) | 135 (48) | 104 (48.8) | 31 (45.6) | |||||
| 2DS3 | + | 107 (33.5) | 93 (33.1) | 0.931 | 65 (30.5) | 28 (41.2) | 0.508 | 0.263 | 0.107 |
| – | 212 (66.5) | 188 (66.9) | 148 (69.5) | 40 (58.8) | |||||
| 2DS4 | + | 305 (95.6) | 266 (94.7) | 0.704 | 199 (93.4) | 67 (98.5) | 0.323 | 0.486 | 0.128 |
| – | 14 (4.4) | 15 (5.3) | 14 (6.6) | 1 (1.5) | |||||
| 2DS5 | + | 86 (27.0) | 99 (35.2) | 0.033c | 85 (39.9) | 14 (20.6) | 0.002f | 0.360 | 0.004g |
| – | 233 (73.0) | 182 (64.8) | 128 (60.1) | 54 (79.4) | |||||
| 3DS1 | + | 129 (40.4) | 132 (47.0) | 0.117 | 105 (49.3) | 27 (39.7) | 0.050h | 1.000 | 0.209 |
| – | 190 (59.6) | 149 (53.0) | 108 (50.7) | 41 (60.3) | |||||
+ presence; – absence; N – total number of individuals; n – number of individuals with the presence or absence of KIR gene. OR – odds ratio with a confidence interval (CI) of 95%. Comparisons were made by the two-sided Fisher´s exact test. Framework genes and pseudogenes were not included. P-values marked in bold are statistically significant (p < 0.05). P1 – p-value obtained comparing total AC patients versus healthy donors; P2 and P3 – p-values obtained comparing non-viral AC patients and viral AC patients versus healthy controls, respectively; P4 – p-value obtained comparing non-viral versus viral AC patients. P5 – p-value obtained comparing VHC cirrhosis patients versus healthy controls.
OR = 1.530; 95% CI: 1.103–2.120, p = 0.013;
OR = 1.575; 95% CI: 1.137–2.183, p = 0.006;
OR = 0.679; 95% CI: 0.479–0.961, p = 0.033;
OR = 1.557; 95% CI: 1.095–2.215, p = 0.015;
OR = 1.625; 95% CI: 1.143–2.311, p = 0.007;
OR = 0.556; 95% CI: 0.384–0.804, p = 0.002;
OR = 2.561; 95% CI: 1.339–4.900, p = 0.004;
OR = 0.698; 95% CI: 0.492–0.991, p = 0.050.