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. 2021 May 17;9:90. doi: 10.1186/s40478-021-01196-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — TAU-SI levels are reduced in Cnr2^−/− mice. a qRT-PCR determination of mRNA levels of MAPT. b Ipsilateral hippocampal tissue obtained from Cnr2^+/+ and Cnr2^−/− AAV-hTAU^P301L injected mice were separated into SS and SI fractions. Levels of p-TAU-AT8 were analysed in by immunoblotting and their respective protein quantifications. n = 3 samples per experimental group ± SEM. Asterisks show significant differences with **p < 0.01 comparing each group according to a Student’s t-test