Fig. 6.

CB₂ is increased in neurofibrillary tangle TAU positive neurons from AD patients. a Scheme of the different Braak stages of AD progression in the human brain: Stages I-II (transenthorinal), stages III-IV (limbic), and stages V-VI (neocortical) (Modified from http://www.thehumanbrain.info/ at the hippocampus level). b qRT-PCR determination of mRNA levels of CNR1 and CNR2. Both measures were normalized by TBP mRNA levels. n = 3–4 ± SEM. Asterisks denote significant differences *p < 0.05, comparing the AD patients with the control condition according to Student's t-test. c Double immunofluorescence staining of 15 μm-thick sections of hippocampal tissue from control (n = 4) and AD (n = 4) patients. Green, anti-CB2. Red, anti-TAU-HT7. Blue, DAPI