Fig. 4. Structure of the K313 analogs and their corresponding IC50 values of PRMT1 inhibition. The compounds are categorized in three series by the structure features. (A) to (D), series 1, compounds with symmetrical features that two indene-like cores connected by a two-carbon linker. (E) to (H), series 2, compounds with a benzamidine moiety is connected at the para-position with an indene-like core. (I), series 3, compounds with various linker lengths.
