Fig. 1.

Pathology of diffuse trophoblastic damage.

A Grossly the placenta is pale and stiffed. B Histologically, there is diffuse collapse of intervillous space resulting in close contact among chorionic villi with necrosis of trophoblast that stains homogeneously with eosin (H&E, original magnification 20x). C At higher power nuclear signs of cell necrosis can be readily seen in the involved trophoblast whereas villous stroma is spared (H&E, original magnification 60x). D Occasional groups of preserved chorionic villi are totally surrounded of villi involved by diffuse trophoblastic damage (H&E, original magnification 10x). E immunohistochemistry for SARS-CoV-2 shows patchy trophoblast staining (original magnification 30x). F in situ hybridization shows a granular pattern of staining in trophoblast lining of chorionic villi (original magnification 30x).