Fig. 1. (A) Superimposition between JAK2 (PDB ID: 3FUP) and EGFR (PDB ID: 1M17) crystal structures. Tofacitinib (white) and erlotinib (dark gray) are shown in a ball and stick model. The sequence alignment of the four conserved regions: catalytic loop, hinge region, glycine loop and activation loop, between JAK2 and EGFR is given in (B), in which the sequence identity is shaded in magenta.
