Fig. 5. (A and B) binding patterns of thiazole-based chalcones and known drugs within JAK2 and EGFR-TK. (C and D) Hydrophobic and hydrophilic surfaces of compound 12/JAK2 and compound 25/EGFR-TK complexes. (E) Structural superimposition between JAK2 and EGFR-TK, especially at the ATP-binding pocket.