Fig. 7. Recent application of F2Pmp in drug design. A) Chemical structure of PTP-MEG2 selective inhibitor 6.32 B) Crystal structure of PTP-MEG2 with inhibitor 6 (PDB code: 4GE6).32 C) Chemical structure of cell-permeable bicyclic peptide PTP1B inhibitor 7.31 D) Chemical structure of ligand 8 for the inhibitor affinity purification of SH2 proteins.33.
