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. 2020 Dec 24;12(3):321–329. doi: 10.1039/d0md00375a

Fragments that have been identified binding to three protein targets and classified by sociability as determined by published methods and close analogues available on eMolecules®.

Protein target Unsociable fragments Sociable fragments
Structure Published method Commercially available close analogues Structure Published method Commercially available close analogues
Urokinase-like plasminogen activator (uPA) Inline graphic1 No55 <5 Inline graphic2 Yes56 >100
Hematopoietic prostaglandin D2 synthase (H-PGDS) Inline graphic3 Yes57 <10 Inline graphic4 Yes58 >250
Hepatitis C virus NS3 protease-helicase Inline graphic5 Yes59 <5 Inline graphic6 Yes60 >1000