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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Toxicol In Vitro. 2020 Dec 29;71:105073. doi: 10.1016/j.tiv.2020.105073

Figure 1.

Figure 1.

Inhibition of iodotyrosine deiodinase (IYD) enzyme activity produced by chemicals in single-concentration screening (ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries plus the 10 chemicals in the replicated test set) at target concentration of 200 μM, displayed as % of control with median (black circle) and range (line) of three biological replicates. [A] All chemicals, [B] Expanded plot of chemicals that produced ≥20% inhibition. Chemicals are plotted by rank order based on median % inhibition in single-concentration screening, with those producing the greatest inhibition to the right. Chemicals further tested in concentration-response screening are indicated with white asterisk (*). The top 25 ranked chemicals based on absolute IC50 are shown in Table 3, with tested concentrations and median % inhibition values for each chemical in Supplementary Table 2.