Fig. 2.

A. Characteristics of an Assessment Framework for PBK Models. Key information and supporting references are addressed in the model reporting template (by the model developer/proponent), while key questions to facilitate confidence assessment in the purpose-specific application of a model are outlined in the evaluation checklist (for use by the assessor/regulator). Considerations (under model validity) in green text do not require in vivo data; those in red require in vivo data. B. The scientific validity (reliability and relevance) of a PBK model. Reliability considerations in green (above), relevance consideration in blue (below). Figure taken from OECD [7]. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)