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. Author manuscript; available in PMC: 2022 Feb 11.
Published in final edited form as: J Med Chem. 2021 Feb 1;64(3):1584–1592. doi: 10.1021/acs.jmedchem.0c01768

Figure 1.

Figure 1.

Domain architecture of NSD2 and chemical evolution of NSD2-PWWP1 antagonists. Receptor-based virtual screening followed by target and scaffold hopping led to the development of 3.