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. 2021 May 17;9(5):e002024. doi: 10.1136/jitc-2020-002024

Table 1.

Receptor affinity of rhIL-15, NKTR-255 and rhIL-15/IL-15Rα

IL-15Rα IL-2Rβ
kon
(M-1sec-1)
koff
(sec-1)
KD
(pM)
kon
(M-1sec-1)
koff
(sec-1)
KD
(nM)
rhIL-15 5.1±1.4×106 9.3±0.97×10-5 19±3.4 6.6±0.54×105 0.036±0.0077 59±16
NKTR-255 7.8±0.74×105 6.7±1.7×10-5 85±14 1.3±0.18×105 0.034±0.0023 260±52
rhIL-15/IL-15Rα ND ND ND 4.0±1.9×106 0.025±0.00099 6.6±0.86

Human IL-15Rα or IL-2Rβ were captured on a Biacore surface plasmon resonance sensor chip and relative affinities were calculated from kinetic measurements. Each assay was performed in duplicate. KD, dissociation constant (affinity); koff, mean dissociation rate constant; kon, mean association rate; ND, not determined.

IL, interleukin; rhIL-15, recombinant human IL-15.