Table 4.
Characteristics associated with favorable outcome in comatose BAO patients.
| n (%)/median (IQR) | All (n = 103) | mRS 0–3 (n = 21, 20.4%) | mRS 4–6 (n = 82, 79.6%) | p |
|---|---|---|---|---|
| Characteristics | ||||
| Male sex | 63 (61.2%) | 14 (66.7%) | 49 (59.8%) | 0.562 |
| Age | 73 (63–79) | 65 (57–74) | 74 (66–80) | 0.010 |
| Diabetes | 18 (17.5%) | 1 (4.8%) | 17 (20.7%) | 0.112 |
| Atrial fibrillation | 29 (28.2%) | 3 (14.3%) | 26 (31.7%) | 0.113 |
| Hypertension | 64 (62.1%) | 13 (61.9%) | 51 (62.2%) | 0.980 |
| Dyslipidemia | 42 (40.8%) | 6 (28.6%) | 36 (43.9%) | 0.202 |
| Chronic heart failure | 12 (11.7%) | 4 (19.0%) | 8 (9.8%) | 0.259 |
| Coronary artery disease | 25 (24.3%) | 5 (23.8%) | 20 (24.4%) | 0.956 |
| Previous myocardial infarction | 15 (14.6%) | 3 (14.3%) | 12 (14.6%) | 1.000 |
| Previous stroke | 25 (24.3%) | 4 (19.0%) | 21 (25.6%) | 0.531 |
| Sudden onset phenotype | 89 (86.4%) | 18 (85.7%) | 71 (86.6%) | 1.000 |
| Prodromes | 19 (18.4%) | 3 (14.3%) | 16 (19.5%) | 0.757 |
| Convulsions | 25 (24.3%) | 5 (23.8%) | 20 (24.4%) | 0.956 |
| Lowest GCS on admission† | 5 (4–6) | 6 (4–7) | 5 (4–6) | 0.212 |
| Radiological parameters | ||||
| pc-ASPECTS < 8 | 30 (29.1%) | 2 (9.5%) | 28 (34.1%) | 0.027 |
| Bilateral ischemia | 36 (35.3%) | 5 (23.8%) | 31 (38.3%) | 0.217 |
| Brainstem ischemia | 24 (23.5%) | 3 (14.3%) | 21 (25.9%) | 0.388 |
| No patent PComs | 29 (29.0%) | 6 (30.0%) | 23 (28.8%) | 0.912 |
| 2 PComs | 43 (43.0%) | 10 (50.0%) | 33 (41.3%) | 0.480 |
| At least one patent PCA | 95 (95.0%) | 19 (95.0%) | 76 (95.0%) | 1.000 |
| At least one patent SCA | 58 (58.0%) | 11 (55.0%) | 47 (58.8%) | 0.761 |
| Long BAO (≥2 segments) | 53 (52.5%) | 11 (55.0%) | 42 (51.9%) | 0.801 |
| BAO exceeding to VA | 32 (32.0%) | 4 (20.0%) | 28 (35.0%) | 0.198 |
| Recanalization (TIMI 2–3)‡ | 57 (74.0%) | 19(95.0%) | 38 (66.7%) | 0.013 |
| sICH (ECASS II) | 14 (13.9%) | 0 (0.0%) | 14 (17.5%) | 0.038 |
| Treatments | ||||
| IVT | 93 (90.3%) | 19 (90.5%) | 74 (90.2%) | 0.974 |
| EVT | 30 (29.1%) | 5 (23.8%) | 25 (30.5%) | 0.548 |
| IVT + EVT | 21 (20.4%) | 3 (14.3%) | 18 (22.0%) | 0.554 |
| Time delays (min) | ||||
| OTT | 282 (158–640) | 247 (165–415) | 305 (158–640) | 0.595 |
| SDT | 158 (85–371) | 170 (106–371) | 156 (82–371) | 0.964 |
| DTN | 85 (38–180) | 89 (51–165) | 85 (38–189) | 0.902 |
Data available in 81%.
Data available in 75%.
mRS, modified Rankin Scale; IQR, interquartile range; GCS, Glasgow Coma Scale; pc-ASPECTS, posterior circulation Acute Stroke Prognosis Early CT Score; PCom, posterior communicating artery; PCA, posterior cerebral artery; SCA, superior cerebellar artery; BAO, basilar artery occlusion; VA, vertebral artery; TIMI, thrombolysis in myocardial infarction; IVT, intravenous thrombolysis; EVT, endovascular treatment; OTT, Onset-to-treatment time; SDT, symptom-to-door time; DTN, Door-to-needle time.
Univariate model; a multivariable regression model was not constructed due to the small sample size.
Statistically significant p-values (<0.05) are bolded.