Table 5.
Factors associated with poorest outcome (mRS 5–6) in comatose BAO patients.
| n (%)/mean (SD)/median (IQR) | All (n = 103) | mRS 0–4 (n = 28, 27.2%) | mRS 5–6 (n = 75, 72.8%) | p |
|---|---|---|---|---|
| Characteristics | ||||
| Male sex | 63 (61.2%) | 19 (67.9%) | 44 (58.7%) | 0.395 |
| Age | 71 (12) | 65 (14) | 73 (10) | 0.001 |
| Diabetes n | 18 (17.5%) | 1 (3.6%) | 17 (22.7%) | 0.022 |
| Atrial fibrillation | 29 (28.2%) | 3 (10.7%) | 26 (34.7%) | 0.016 |
| Hypertension | 64 (62.1%) | 18 (64.3%) | 46 (61.3%) | 0.783 |
| Dyslipidemia | 42 (40.8%) | 9 (32.1%) | 33 (44.0%) | 0.276 |
| Chronic heart failure | 12 (11.7%) | 4 (14.3%) | 8 (10.7%) | 0.731 |
| Coronary artery disease | 25 (24.3%) | 7 (25.0%) | 18 (24.0%) | 0.916 |
| Previous myocardial infarction | 15 (14.6%) | 3 (10.7%) | 12 (16.0%) | 0.754 |
| Previous stroke | 25 (24.3%) | 6 (21.4%) | 19 (25.3%) | 0.681 |
| Sudden onset phenotype | 89 (86.4%) | 25 (89.3%) | 64 (85.3%) | 0.753 |
| Prodromes | 19 (18.4%) | 4 (14.3%) | 15 (20.0%) | 0.506 |
| Convulsions | 25 (24.3%) | 7 (25.0%) | 18 (24.0%) | 0.916 |
| Lowest GCS on admission† | 5 (4–6) | 6 (5–7) | 4 (3–6) | 0.026 |
| Radiological parameters | ||||
| pc-ASPECTS < 8 | 30 (29.1%) | 2 (7.1%) | 28 (37.3%) | 0.003 |
| Bilateral ischemia | 36 (35.3%) | 5 (17.9%) | 31 (41.9%) | 0.023 |
| Brainstem ischemia | 24 (23.5%) | 3 (10.7%) | 21 (28.4%) | 0.061 |
| No patent PComs | 29 (29.0%) | 9 (33.3%) | 20 (27.4%) | 0.561 |
| 2 PComs | 43 (43.0%) | 13 (48.1%) | 30 (41.1%) | 0.527 |
| At least one patent PCA | 95 (95.0%) | 25 (92.6%) | 70 (95.9%) | 0.610 |
| At least one patent SCA | 58 (58.0%) | 14 (51.9%) | 44 (60.3%) | 0.449 |
| Long BAO (≥2 segments) | 53 (52.5%) | 14 (51.9%) | 39 (52.7%) | 0.940 |
| BAO exceeding to VA | 32 (32.0%) | 6 (22.2%) | 26 (35.6%) | 0.202 |
| Recanalization (TIMI 2–3)‡ | 57 (74.0%) | 25 (92.6%) | 32 (64.0%) | 0.006 |
| sICH (ECASS II) | 14 (13.9%) | 0 (0.0%) | 14 (19.2%) | 0.010 |
| Treatments | ||||
| IVT | 93 (90.3%) | 26 (92.9%) | 67 (89.3%) | 0.724 |
| EVT | 30 (29.1%) | 8 (28.6%) | 22 (29.3%) | 0.940 |
| IVT + EVT | 21 (20.4%) | 6 (21.4%) | 15 (20.0%) | 0.873 |
| Time delays (min) | ||||
| OTT | 282 (158–640) | 235 (162–379) | 315 (158–642) | 0.237 |
| SDT | 158 (85–371) | 159 (98–368) | 158 (82–451) | 0.961 |
| DTN | 85 (38–180) | 69 (38–127) | 89 (38–214) | 0.216 |
Data available in 81%.
Data available in 75%.
mRS, modified Rankin Scale; SD, Standard deviation; IQR, interquartile range; GCS, Glasgow Coma Scale; pc-ASPECTS, posterior circulation Acute Stroke Prognosis Early CT Score; PCom, posterior communicating artery; PCA, posterior cerebral artery; SCA, superior cerebellar artery; BAO, basilar artery occlusion; VA, vertebral artery; TIMI, thrombolysis in myocardial infarction; IVT, intravenous thrombolysis; EVT, endovascular treatment; OTT, Onset-to-treatment time; SDT, symptom-to-door time; DTN, Door-to-needle time.
Univariate model; a multivariable regression model was not possible to construct due to the small sample size.
Statistically significant p-values (<0.05) are bolded.