Table 2.
Phosphosites differentially expressed in ARC-C vs ARC-N.
| Protein names | Gene name | Accession | Score | Modified sequence | Position | FC | p value |
|---|---|---|---|---|---|---|---|
| Phosphosites exclusively detected in ARC-C | |||||||
| Actin, cytoplasmic 1 | ACTA2 | P60709 | 111.6 | _GYS(ph)FTTTAER_ | 199 | NaN | 0.006 |
| Alcohol dehydrogenase 1A | ADH1A | V9HW89 | 93.73 | _SGGTLVLVGLGS(ph)EMTTVPLLHAAIR_ | 277 | NaN | 0.024 |
| Alcohol dehydrogenase 1A | ADH1A | V9HW89 | 82.89 | _EIGADLVLQISKES(ph)PQEIAR_ | 228 | NaN | ≤0.001 |
| Alcohol dehydrogenase 1A | ADH1A | V9HW89 | 105.8 | _S(ph)GGTLVLVGLGSEMTTVPLLHAAIR_ | 266 | NaN | 0.001 |
| Cysteine protease | ATG4D | B4DZK0 | 64.3 | _KYS(ph)IFTEKDEILSDVASR_ | 151 | NaN | 0.001 |
| Alpha-crystallin A chain | CRYAA | P02489 | 142.5 | _HFSPEDLT(ph)VK_ | 86 | NaN | ≤0.001 |
| Beta-crystallin A2 | CRYBA2 | P53672 | 85.46 | _LLS(ph)DCANVCER_ | 31 | NaN | 0.026 |
| Beta-crystallin A4 | CRYBA4 | P53673 | 86.48 | _GFQYVLECDHHS(ph)GDYK_ | 170 | NaN | 0.015 |
| Beta-crystallin B1 | CRYBB1 | P53674 | 162.4 | _WNTWSS(ph)SYR_ | 129 | NaN | 0.016 |
| Quinone oxidoreductase | CRYZ | Q08257 | 98.77 | _AGESVLVHGAS(ph)GGVGLAACQIAR_ | 158 | NaN | ≤0.001 |
| Eukaryotic initiation factor 4A-II | EIF4A2 | Q14240 | 137.9 | _GYDVIAQAQS(ph)GTGK_ | 79 | NaN | ≤0.001 |
| Protein 4.1 | EPB41 | P11171 | 99.02 | _QAS(ph)ALIDRPAPHFER_ | 521 | NaN | ≤0.001 |
| Glucose-6-phosphate isomerase (fragment) | GPI | A0A0A0MTS2 | 65.72 | _ELQAAGKS(ph)PEDLER_ | 470 | NaN | ≤0.001 |
| Heat shock 70 kDa protein 4 | HSPA4 | P34932 | 63.71 | _AFS(ph)DPFVEAEK_ | 76 | NaN | ≤0.001 |
| Glutathione synthetase | GSS | P48637 | 68.94 | _DGY(ph)MPRQYSLQNWEAR_ | 270 | NaN | 0.003 |
| Phakinin | BFSP2 | Q13515 | 110.9 | _AAEEEINS(ph)LYK_ | 208 | NaN | ≤0.001 |
| Phakinin | BFSP2 | Q13515 | 58.69 | _VHALEQVSQELET(ph)QLR_ | 134 | NaN | 0.006 |
| Lactase-like protein | LCT | Q6UWM7 | 86.29 | _S(ph)AEQGLEM(ox)SR_ | 311 | NaN | ≤0.001 |
| L-Lactate dehydrogenase A chain | LDHC | P00338 | 90.61 | _S(ph)ADTLWGIQK_ | 319 | NaN | 0.028 |
| Neurofascin | NRCAM | O94856 | 78.34 | _SGT(ph)LVIDFR_ | 98 | NaN | ≤0.001 |
| Protein kinase C and casein kinase substrate in neurons 3 | PACSIN3 | D3DQR0 | 92.54 | _LKEVEAS(ph)K_ | 153 | NaN | 0.001 |
| Peroxisome biogenesis factor 10, isoform CRA_b | PEX10 | A0A024R0A4 | 87.26 | _RAS(ph)LEER_ | 281 | NaN | 0.006 |
| Phosphoglycerate mutase 1 | PGAM1 | P18669 | 56.72 | _FSGWYDADLS(ph)PAGHEEAKR_ | 31 | NaN | 0.016 |
| Plectin | PLEC | Q15149 | 93.16 | _LS(ph)FSGLR_ | 3441 | NaN | ≤0.001 |
| Plectin | PLEC | Q15149 | 69.72 | _KAS(ph)DSELER_ | 2039 | NaN | ≤0.001 |
| Plectin | PLEC | Q15149 | 78.65 | _KES(ph)YSALMR_ | 794 | NaN | 0.007 |
| cAMP-dependent protein kinase catalytic subunit alpha | PRKACA | P17612 | 68.11 | _KGS(ph)EQESVK_ | 11 | NaN | ≤0.001 |
| Ribose-phosphate diphosphokinase | PRPS2 | A0A140VK41 | 53.87 | _VAILVDDMADT(ph)CGTICHAADK_ | 228 | NaN | ≤0.001 |
| Glycogen phosphorylase | PYGB | P06737 | 61.64 | _RMS(ph)LIEEEGSKR_ | 430 | NaN | 0.002 |
| SEC14-like protein 2 | SEC14L2 | O76054 | 122.5 | _VGDLS(ph)PR_ | 9 | NaN | ≤0.001 |
| Tryptophan-tRNA ligase, cytoplasmic | WARS | P23381 | 99.8 | _KLS(ph)FDFQ_ | 467 | NaN | 0.002 |
| Synaptobrevin homolog YKT6 | YKT6 | O15498 | 53.03 | _IDWPVGS(ph)PATIHYPALDGHLSR_ | 114 | NaN | 0.010 |
| 14-3-3 protein | YWHAH | Q04917 | 51.15 | _KNS(ph)VVEASEAAYK_ | 145 | NaN | ≤0.001 |
| Phosphosites exclusively detected in ARC-N | |||||||
| Nucleoside triphosphate pyrophosphatase | ASMT | O95671 | 80.98 | _VVLASAS(ph)PR_ | 21 | NaN | ≤0.001 |
| Alpha-crystallin B chain | CRYAA | P02511 | 127 | _LFDQFFGEHLLESDLFPTSTSLS(ph)PFYLRPPSFLR_ | 45 | NaN | 0.010 |
| Crystallin gamma B | CRYGB | A0A0U3BWM0 | 73.78 | _GQMSELT(ph)DDCLSVQDR_ | 107 | NaN | 0.004 |
| 3-Hydroxyanthranilate 3,4-dioxygenase | HAAO | P46952 | 78.43 | _RLS(ph)LAPDDSLLVLAGTSYAWER_ | 247 | NaN | 0.007 |
| Phosphosites with upregulation in ARC-C (selected) | |||||||
| Beta-crystallin A3 | CRYBA1 | P05813 | 69.26 | _ITIY(ph)DQENFQGK_ | 36 | #### | ≤0.001 |
| Alpha-crystallin B chain | CRYAA | P02511 | 177.9 | _RPFFPFHSPS(ph)R_ | 21 | #### | 0.049 |
| Phakinin | BFSP2 | Q13515 | 174.6 | _SS(ph)SSLES(ph)PPASR_ | 38 | #### | ≤0.001 |
| Alpha-crystallin B chain | CRYAA | P02511 | 151.2 | _LEKDRFS(ph)VNLDVK_ | 76 | #### | 0.001 |
| Filensin | BFSP1 | Q12934 | 173.6 | _VRS(ph)PKEPETPTELYTK_ | 454 | #### | 0.009 |
| Phosphosites with downregulation in ARC-C | |||||||
| Beta-crystallin A3 | CRYBA1 | P05813 | 252.2 | _RMEFTS(ph)SCPNVSER_ | 50 | 0.26 | 0.005 |
| Gamma-crystallin D | CRYGD | P07320 | 151.2 | _RGDYADHQQWMGLS(ph)DSVR_ | 73 | 0.27 | 0.009 |
| Coactosin-like protein | COTL1 | Q14019 | 70.09 | _FTTGDAMS(ph)KR_ | 71 | 0.45 | ≤0.001 |
| Beta-crystallin A3 | CRYBA1 | P05813 | 123.4 | _WDAWS(ph)GSNAYHIER_ | 100 | 0.50 | 0.049 |