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. Author manuscript; available in PMC: 2022 May 12.
Published in final edited form as: ACS Appl Mater Interfaces. 2021 Apr 29;13(18):20921–20937. doi: 10.1021/acsami.1c01389

Figure 3.

Figure 3.

pSBMA grafted from the surface of Ti6Al4V IM pins combined with a single vancomycin injection (Ti-pSBMA+VAN) more effectively suppressed S. aureus periprosthetic infection in mouse femoral canals than pSMBA coating alone (Ti-pSBMA) or the single systemic vancomycin injection alone (Ti6Al4V+VAN). (a) μ-CT axial view of the femur at day 21 (pins contoured out). (b) μ-CT quantitation of bone volume fraction (BVF), bone mineral density (BMD) and cortical thickness (C. Th) at day 21. *P<0.05, **P<0.01, ***P<0.001. All femurs were inoculated with 40-CFU Xen 29 prior to pin insertion. Reproduced with the permission from ref 93. Copyright 2020 American Chemical Society.