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Schematic illustration of possible antibacterial mechanisms on the surface of Ti6Al4V5Cu implants. Ti6Al4V5Cu releases Cu ions. The released Cu ions could accumulate in the cell membrane affecting membrane permeability, disrupt the activity of respiratory chain, enter bacterial cells to generate ROS, and disrupt the gene replication of S. aureus. Reproduced with the permission from ref 146. Copyright 2015 Wiley Publication.
