(a) IVIS images of mouse femurs injected with 40 CFU Xen-29 S. aureus and inserted with IM pins with PEGDMA-Oligo-Vanco or PEGDMA-Oligo coatings at 2, 7, 14, and 21 days. (b) Quantification of longitudinal bioluminescence signals of mouse femurs injected with 40 CFU Xen-29 S. aureus and inserted with the different hydrogel-coated pins at 2, 7, 14, and 21 days (n = 14). (c) S. aureus recovery from explanted pins at 21 days (n = 11). (d) 3D μCT axial images of the distal femoral region 21 days after the insertion of Ti6Al4V IM pins (pins excluded during contouring) with different hydrogel coatings, with or without the inoculation of 40-CFU Xen-29 S. aureus. Error bars represent standard deviations. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001 (two-way ANOVA for part b; Student’s t-test for part c). Reproduced with the permission from ref 21. Copyright 2019 American Chemical Society.