Summary of findings 5. Cefdinir compared to cefalexin for bacterial folliculitis and boils (furuncles and carbuncles).
| Cefdinir compared to cefalexin for bacterial folliculitis and boils (furuncles and carbuncles) | |||||
| Patient or population: bacterial folliculitis and boils (furuncles and carbuncles) Setting: hospital Intervention: cefdinir Comparison: cefalexin | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with cefalexin | Risk with cefdinir | ||||
| Clinical cure (measured 17 to 24 days after treatment) |
Study population | RR 1.00 (0.73 to 1.38) | 74 (1 RCT) | ⊕⊕⊝⊝ LOW 1 | |
| 760 per 1000 | 770 per 1000 (670 to 876) | ||||
| Severe adverse events leading to withdrawal of treatment (reported during 17 to 24 days of treatment) |
Study population | RR 1.05 (0.07 to 16.62) | 3912 (1 RCT) | ⊕⊕⊝⊝ LOW 1 | |
| 5 per 1000 | 5 per 1000 (0 to 83) | ||||
| Quality of life | Not measured | ||||
| Recurrence of folliculitis or boil following completion of treatment | Not measured | ||||
| Minor adverse events not leading to withdrawal of treatment | Not reported. But the authors do state that of the 391 participants who received study medications, 10% in the cefdinir group and 4% in the cefalexin group experienced diarrhoea (P = 0.017), 3% and 6% nausea, respectively (P = 0.203), and 3% and 6% of females experienced vaginal mycosis (P = 0.500) during therapy. | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||
1Downgraded one level due to high risk of performance bias and one level for imprecision (confidence interval included 1.0). 2The complete study participants were included in adverse event analysis.